Opposing modulatory effects of D 1 - and D 2 - like receptor activation on a 3 spinal central pattern generator 4 5 6
نویسنده
چکیده
1 2 Opposing modulatory effects of D1and D2-like receptor activation on a 3 spinal central pattern generator 4 5 6 7 8 S. Clemens , A. Belin-Rauscent , J. Simmers *, D. Combes * 9 10 11 12 1 Brody School of Medicine, Department of Physiology, East Carolina University, 13 Greenville, NC 27834, USA 14 2 Université de Bordeaux, CNRS, INCIA, UMR 5287, 33076 Bordeaux, France 15 16 17 18 19 Running title: Opposing dopamine modulation of a locomotory CPG 20 21 22 23 24 25 26
منابع مشابه
Opposing modulatory effects of D1- and D2-like receptor activation on a spinal central pattern generator.
The role of dopamine in regulating spinal cord function is receiving increasing attention, but its actions on spinal motor networks responsible for rhythmic behaviors remain poorly understood. Here, we have explored the modulatory influence of dopamine on locomotory central pattern generator (CPG) circuitry in the spinal cord of premetamorphic Xenopus laevis tadpoles. Bath application of exogen...
متن کاملTitle: Dopaminergic Modulation of Locomotor Network Activity in the Neonatal Mouse Spinal Running Title: Dopaminergic Modulation of Locomotion Introduction
19 20 Dopamine is now well established as a modulator of locomotor rhythms in a variety of 21 developing and adult vertebrates. However, in mice while all five dopamine receptor subtypes 22 are present in the spinal cord it is unclear which receptor-subtypes modulate the rhythm. 23 Dopamine receptors can be grouped into two families – the D 1/5 receptor group and the D 2/3/4 24 group that have ...
متن کاملDopaminergic modulation of locomotor network activity in the neonatal mouse spinal cord.
Dopamine is now well established as a modulator of locomotor rhythms in a variety of developing and adult vertebrates. However, in mice, while all five dopamine receptor subtypes are present in the spinal cord, it is unclear which receptor subtypes modulate the rhythm. Dopamine receptors can be grouped into two families-the D1/5 receptor group and the D2/3/4 group, which have excitatory and inh...
متن کاملThe Modulatory Effects of Vitamin D on the Expression of IL-12 and TGF-β in the Spinal Cord and Serum of Mice with Experimental Autoimmune Encephalomyelitis
Background & objective The immunoregulatory effects of transforming growth factor (TGF)-βand interleukin-12 (IL-12) and immunomodulatory actions of vitamin D (VD) were reported in several studies. This study aims to evaluate VD effects on IL-12 and TGF-β expression in experimental autoimmune encephalomyelitis (EAE). Methods:</str...
متن کاملMechanisms underlying the endogenous dopaminergic inhibition of spinal locomotor circuit function in Xenopus tadpoles
Dopamine plays important roles in the development and modulation of motor control circuits. Here we show that dopamine exerts potent effects on the central pattern generator circuit controlling locomotory swimming in post-embryonic Xenopus tadpoles. Dopamine (0.5-100 μM) reduced fictive swim bout occurrence and caused both spontaneous and evoked episodes to become shorter, slower and weaker. Th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2011